Studies on the Relationship of Alloxan-diabetes
نویسنده
چکیده
A reduction in the size and incidence of tumors has been shown to occur in alloxanized Wistar rats given injections intraperi@oneally of homogenates of the transplantable Novikoff hepatoma (9, 10). Salzberg and Griffin (@6)likewise demonstrated a reduction in the incidence of DAB-induced hepa tomas in alloxanized rats, and Vangerov and Mc Kee (80) have recently reported a diminution in the growth of Ehrlich ascites carcinoma cells in alloxan-diabetic C57/6BL mice. A reciprocal effect of the Novikoff tumors in producing a significant lowering of the fasting blood sugar values in the alloxanized rats was also consistently found (9, 10). Since Carrie and Ham, in an earlier report (8), observed no reduction in the fasting blood sugar levels in alloxanized Wistar rats given @ubcutane
منابع مشابه
تأثیر آنتیاکسیدانی منیزیم بر اسیدهای چرب آزاد پلاسما در رتهای دیابتی شده با آلوکسان
Background: Alloxan is on of the xenobiotic agents which is classified as diabetogenic materials. Magnesium is an important cofactor regulating the activity of carbohydrate enzymes and lipid synthesis. In this study the contrasting effects of Alloxan and magnesium on plasma free fatty acids (FFA) in rats was investigated. Methods: Male mature rats were used as test models for the diabetes induc...
متن کاملEffects of safflower oil on FBS and lipid profile in alloxan induced diabetic rats and its mechanism
Background & Aim: Diabetes mellitus often has been referred to as a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormal of high blood sugar levels (hyperglycemia). Nowadays, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. Experimental: This study aimed at assessing the...
متن کاملEffects of safflower oil on FBS and lipid profile in alloxan induced diabetic rats and its mechanism
Background & Aim: Diabetes mellitus often has been referred to as a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormal of high blood sugar levels (hyperglycemia). Nowadays, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. Experimental: This study aimed at assessing the...
متن کاملThe effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
Diabetes is one of the most common diseases in all societies including Iran. One of its important complications is the neuropathic pain, which can be relieved by opioid drugs such as morphine. Opioid therapy is restricted due to development of tolerance and physical or mental dependence. In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and depend...
متن کاملThe effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
Diabetes is one of the most common diseases in all societies including Iran. One of its important complications is the neuropathic pain, which can be relieved by opioid drugs such as morphine. Opioid therapy is restricted due to development of tolerance and physical or mental dependence. In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and depend...
متن کاملEffect of Hydroalcoholic Extract of Glaucium flavum Crantz on Thyroid Hormones in Alloxan Diabetic Rats
Background: Thyroid dysfunction is one of the controversial complications of diabetes. Given the hypoglycemic properties of Yellow Horne Poppy (YHP), this study was conducted to evaluate the effect of oral administration of aqua-ethanolic extract of YHP and glibenclamide on serum level of T3 and T4 hormones in alloxan diabetic rats compared to healthy rats. Materials and Methods: In this exper...
متن کامل